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Schedules
NFL Series Records
NFL Series Records
Last 20 Years San Francisco 49ers vs Buffalo Bills (Bills 3-2-0)
Click scores for game stats. Helmets courtesy The Helmet Project.
| Season | Date | Week | Away | Score | Home |
|---|---|---|---|---|---|
| 2024 | Sun Dec 1, 2024 | 13 |  San Francisco 49ers |  Buffalo Bills | |
| 2020 | Mon Dec 7, 2020 | 13 | Buffalo Bills (47)  | 34-24 | San Francisco 49ers -1 |
| 2016 | Sun Oct 16, 2016 | 6 | San Francisco 49ers | 16-45 | Buffalo Bills |
| 2012 | Sun Oct 7, 2012 | 5 | Buffalo Bills | 3-45 | San Francisco 49ers |
| 2008 | Sun Nov 30, 2008 | 13 |  San Francisco 49ers | 10- 3 |  Buffalo Bills |
| 2004 | Sun Dec 26, 2004 | 16 | Buffalo Bills | 41- 7 | San Francisco 49ers |
